Hematological and Coagulation Profile in Dengue Cases Admitted at Tertiary Care Hospital

Background: Dengue is one of the important public health problems in India. The main laboratory abnormalities found in dengue are thrombocytopenia, leukopenia, haemoconcentration & derangement of coagulation profile. Aim and objective: To study haematological and coagulation profile in dengue cases admitted at tertiary care hospital, Gujarat.Materials and Methods: This is an observational study of 74 (M - 44, F - 30) cases with diagnosis of dengue for period of one year. Data taken from patient’s blood sample sent for routine investigation at haematology & microbiology laboratory. Reading of haematological and coagulation profile were collected, compiled and analysed. Result: Majority of case 48.65% having dengue infection belong to the age group of 15 - 30 years. Thrombocytopenia was found in 71.62% patients, leukopenia in 39.18% patients and low haematocrit value in 67.56% patients. High MPV observed in 40.54% cases and high MPDW observed in 44.59% cases. Prolonged PT and aPTT observed in 71.62% and 27.03% cases respectively and elevated D - dimer observed in 74.32% cases.Conclusion: The result showed that increasing severity of thrombocytopenia and leukopenia associated with advanced clinical spectrum. Haematocrit, MPV and MPDW are variable with different clinical spectrum of dengue. So, correlation of deranged coagulation parameter like D - Dimer, PT and aPTT can be used as markers for predicting more severe forms of clinical spectrum of dengue.