Left Atrial Myxoma: An Enigma in Itself – Two Case Reports

Background: Cardiac myxomas are rare primary cardiac tumours with variable clinical presentation.Case Presentation: We report two cases of left atrial myxoma, a 40-year-old female with dyspnoea and syncopal episodes, and a 16-year-old male with atypical chest pain and a prior neurological event. Routine laboratory parameters and ECG were unremarkable in both cases, while transthoracic echocardiography and CECT chest identified left atrial masses. Both patients underwent surgical excision. Histopathology revealed classic myxoma morphology with nests and cords of lepidic cells in a myxoid matrix. The older patient developed postoperative sepsis and expired, whereas the adolescent recovered uneventfully.Conclusion: These two case reports highlight the broad age spectrum and diverse clinical manifestations of left atrial myxoma, reinforcing the importance of timely imaging and histopathological confirmation.