Comprehensive immuno-hormonal assessment of the risk of breast cancer in postmenopauseal women

The study aimed to determine the personal combinations of blood serum estradiol and progesterone (E2 and Pg), classes A and G antibodies against E2, Pg and Benzo[a]pyrene (IgA 1 -E2, IgA 1 -Pg, IgA 1 -Bp; IgG 1 -E2, IgG 1 -Pg, IgG 1 -Bp), class G antiidiotypic antibodies to E2 and Pg (IgG 2 -E2, IgG 2 -Pg) levels associated with breast cancer in postmenopausal women. Material and Methods . There were investigated 763 nonsmoking women: 206 healthy and 557 breast cancer patients (BCP) with I stage BC before treatment. The blood serum levels of hormones and antibodies were studied using competitive and non-competitive enzyme immunoassay, respectively. Statistical analysis of the results was performed using Statistica 13.0 Software, Classification and Regression Trees (CART-analysis). Results . There were revealed 7 groups according to personal combinations of IgG 2 -E2, E2, IgA 1 -E2, Pg, and IgG1-Bp associated with BC risk. High E2 levels in combination with high IgG 1 -Bp levels were revealed in 54.2 % of BCP vs 26.7 % of healthy women (p