Enhancer-Based AAV Approach for Selective AADC Delivery Reduces Motor Symptoms and Dyskinesia in Parkinson’s Mouse Models

SSRN Electronic Journal 2026 Preprint Open access

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Authors: Ananya Chowdhury, Alex Fraser, Maxwell Departee, Naz Taskin, Meagan A. Quinlan, John K. Mich, Victoria Omstead, Nathaly Lerma, Ximena Opitz-Araya, Alex C. Hughes, Emily Kussick, Refugio A. Martinez
+26 more Melissa Reding, Elizabeth Liang, Lyudmila Shulga, Dean F. Rette, Cindy Huang, Brittny Casian, Madison Leibly, Olivia Helback, Tyler Barcelli, Toren Wood, Nicholas Uribe, Colin H.C. Bacon, Jessica Bowlus, Dakota Newman, Rana Kutsal, Shannon Khem, Nicholas P. Donadio, Shenqin Yao, Kara Ronellenfitch, Vonn Wright, Kathryn M. Gudsnuk, Gregory D. Horwitz, Boaz P. Levi, Ed S. Lein, Jonathan T. Ting, Tanya L. Daigle
DOI: 10.2139/ssrn.6227388
Cited by: 0

Fields of Study & Subjects

Virus-based gene therapy research Parkinson's Disease Mechanisms and Treatments Neurological disorders and treatments

Publication details

Journal / source
SSRN Electronic Journal
Publication date
1 January 2026
Language
EN
Document type
Preprint