Female iPSC X-chromosome Inactivation (XCI) Erosion and Its transcriptomic Effects During CRISPR Gene Editing and Neural Differentiation

SSRN Electronic Journal 2026 Preprint Open access

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Authors: Christina Thapa, Emily Oh, David Sirkin, Jennifer Lahey, Sol Díaz de León Guerrerro, Ada McCarroll, Prarthana Gowda, Hanwen Zhang, Alexandra Barishman, Lilia Peyton, Siwei Zhang, Rebecca M. Pollak
+7 more Ronald P. Hart, Carlos N. Pato, Anat Kreimer, Jennifer Gladys Mulle, Alan R. Sanders, Zhiping P. Pang, Jubao Duan
DOI: 10.2139/ssrn.6447244
Cited by: 1

Fields of Study & Subjects

CRISPR and Genetic Engineering Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities Pluripotent Stem Cells Research

Publication details

Journal / source
SSRN Electronic Journal
Publication date
1 January 2026
Document type
Preprint