Global, Regional and National Burden of Cervical Cancer and Associated Risk Factors From 1990 to 2023 and Forecasts to 2050: A Systematic Analysis for the Global Burden of Disease Study 2023

<span>Despite being highly preventable, </span><span>cervical cancer</span><span> remains </span><span>one of the</span><span> most common </span><span>malignancies</span><span> among women worldwide. </span><span>The global community has committed to expanding cervical cancer prevention and control with the goal of eventual elimination. </span><span>To assess progress and anticipate future trends, the Global Burden of </span><span>Disease (GBD) </span><span>study </span><span>2023 offers estimates of historical </span><span>cervical cancer burden and provides forecasts through 2050.</span><span> <span>W</span></span><span>e generated estimates of cervical cancer incidence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) by age, location, and year across 204 countries and territories from 1990 to 2023. </span><span>Data from vital registration systems and population-based cancer registries were synthesised using meta-analytical techniques. </span><span>Incidence and mortality were forecast from 2024 to 2050 using the GBD forecasting framework.</span><span> <span>Our results show pronounced geographical disparities: the age-standardised incidence rate (ASIR) in the World Bank low-income group was more than four times higher than in the high-income group, and the age-standardised mortality rate (ASMR)</span></span><span> was more than seven times higher. Between 1990 and 2023, the ASIR of cervical cancer declined in the high-income group; however, no change was found in other groups. Our forecasts suggest that by 2050, the largest burden of ASIR and ASMR will remain in low-income countries.</span><span> <span>Existing strategies fall short of what is needed to achieve elimination.</span></span><span> </span><span>Divergent incidence and mortality trends by income groups reflect persistent inequities in prevention, diagnosis, and treatment</span><span>, calling for intensified efforts to effectively address this preventable condition.</span><span></span>