Trem2 Signaling Exploits Combinatorial Binding of MITF/TFE and ATF/AP-1 Transcription Factors to Drive Disease-Responsive Microglia Phenotypes

SSRN Electronic Journal 2026 Preprint Open access

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Authors: Johannes C. M. Schlachetzki, Dan Zhang, Jean Paul Chadarevian, Nathanael J. Spann, Pik Ki Lau, Kilian L. Kleemann, Xiaoming Zhang, Róisín M. McManus, Fatir A. Qureshi, Olivia Corradin, Sydney O'Brien, Thomas A Prohaska
+20 more Payam A. Saisan, Christopher D. Balak, Vini Tiwari, Amanda McQuade, Khaled Mansour, Hayk Davtyan, Vishal Sarsani, Beth Stevens, Geidy E. Serrano, Thomas G. Beach, Michael Thomas Heneka, Sara Rosenthal, Oleg Butovsky, Nathan R. Zemke, Bing Yang, Seoyeon Lee, Natalia Jimenez-Villegas, Alexi Nott, Mathew M. Blurton-Jones, Christopher K. Glass
DOI: 10.2139/ssrn.7072652
Cited by: 1

Fields of Study & Subjects

Neuroinflammation and Neurodegeneration Mechanisms Inflammation biomarkers and pathways Neurogenesis and neuroplasticity mechanisms

Publication details

Journal / source
SSRN Electronic Journal
Publication date
1 January 2026
Document type
Preprint