Sonidegib Therapy for Locally Advanced Basal Cell Carcinoma in an Elderly Patient: A Case Report

Clinical Cosmetic and Investigational Dermatology 2026 Open access

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Authors: Yuyu Deng, Pingxiu He, Changxia Li, Guolan Li, Xiaohua Tao
DOI: 10.2147/ccid.s584651
Cited by: 0
References: 10

Abstract

We report a case of locally advanced basal cell carcinoma (BCC) of the nose successfully treated with oral sonidegib. An 87-year-old man presented with a pruritic brown papule in the right nasolabial fold, progressively enlarging for >10 years and ulcerated for 7 years. Histopathology confirmed nodular BCC with tumor thickness ≥6 mm. Sonidegib (200 mg daily) was initiated, and a complete resolution was achieved after 5 months. No recurrence or significant adverse effects were observed 4 months post-treatment.

Fields of Study & Subjects

Nonmelanoma Skin Cancer Studies Hedgehog Signaling Pathway Studies Head and Neck Cancer Studies

Publication details

Journal / source
Clinical Cosmetic and Investigational Dermatology
Volume
Volume 19
Pages
1–7
Publication date
1 January 2026
Language
EN