The Shifting Prognostic Value of Performance Status in Aging Glioblastoma Patients: A Retrospective Cohort Study

Purpose: To evaluate how advancing age affects the prognostic value of preoperative versus postoperative Karnofsky Performance Status (KPS) for guiding clinical interventions in glioblastoma (GBM) patients aged 60 and older. Patients and Methods: This retrospective cohort study included 89 patients (≥60 years) with newly diagnosed GBM treated between 2017 and 2021. We analyzed demographic, clinical, and treatment data, identifying prognostic factors for overall survival (OS) via Cox proportional hazards models. The utility of preoperative and postoperative KPS was assessed in age-stratified subgroups (60-64, 65-69, and ≥70 years) using Kaplan-Meier analysis. Results: Multivariable analysis confirmed greater extent of resection (P