The Application Prospects and Future Outlook of Kadsura coccinea (Lem). A.C.Sm. in Rheumatoid Arthritis

Abstract: Kadsura coccinea (Lem). A.C.Sm. has a long history of use in traditional Dong medicine for activating Qi, relieving pain, and dispersing blood stasis. It has garnered increasing attention for treating rheumatoid arthritis (RA), a condition associated with synovial inflammation and tissue damage. K. coccinea L. effects anti-RA by eliminating reactive oxygen species and directly or indirectly inhibiting lipid peroxidation. This review summarizes its potential therapeutic effects on RA through regulating inflammatory cytokines, reducing oxidative stress, and targeting specific cells and pathways, forecasting its future application prospects. Keywords: Kadsura coccinea Lem. A.C.Sm., rheumatoid arthritis, triterpenoids, sesquiterpenes, antioxidant, immunomodulatory