Combination of Ceftazidime-Avibactam and Meropenem for the Treatment of Pneumonia and Bloodstream Infections Caused by Pan-Drug Resistant Pseudomonas aeruginosa ST244: A Case Report

Infection and Drug Resistance 2026 Open access

Read full text
Authors: Yixin Kang, Suhai Kang, Junchang Cui
DOI: 10.2147/idr.s575082
Cited by: 1
References: 8

Abstract

Case Presentation: We describe a challenging case of a woman with Pseudomonas aeruginosa pneumonia and bloodstream infections following cardiothoracic surgery. This strain exhibited a pan-drug resistance phenotype belonging to the high-risk clone ST244. Finally, she was successfully treated by antibiotic therapy with ceftazidime/avibactam (CAZ/AVI) and meropenem (MEPM). Conclusion: This case suggests that the combination of CAZ/AVI and MEPM may represent a potential therapeutic option for severe infections caused by pan-drug-resistant Pseudomonas aeruginosa (PDR-PA). Keywords: ceftazidime/avibactam, meropenem, pan-drug resistance, Pseudomonas aeruginosa

Fields of Study & Subjects

Antibiotic Resistance in Bacteria Antibiotics Pharmacokinetics and Efficacy Infections and bacterial resistance

Publication details

Journal / source
Infection and Drug Resistance
Publisher
Informa UK Limited
Volume
Volume 19
Pages
1–5
Publication date
1 April 2026
Language
EN