Hidden Toll of CRE Colonization: Tripled Three-Year Mortality Risk and Increased Bloodstream Infection Burden After Allo-HSCT—A Propensity-Adjusted Study

Infection and Drug Resistance 2026 Open access

Read full text
Authors: Yuan Zhang, Rong Wang, Guoqing Lyu, Lihua Wang, Xiankai Liu, Linlin Tian, Yan Huang, Jiesen Kou, Sun Wu, Weijie Cao
DOI: 10.2147/idr.s579493
Cited by: 0
References: 33

Abstract

Purpose: Carbapenem-resistant Enterobacteriaceae (CRE) colonization poses a major threat to the success of allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, evidence on its long-term impact and the role of decolonization strategies remains limited. Methods: This study included 240 allo-HSCT recipients prospectively screened for pre-transplant rectal CRE colonization (colonized n=80; non-colonized n=160; 1:2 matching). Inverse probability of treatment weighting (IPTW) was applied to achieve covariate balance (standardized mean difference

Fields of Study & Subjects

Antibiotic Resistance in Bacteria Neutropenia and Cancer Infections Hematopoietic Stem Cell Transplantation

Publication details

Journal / source
Infection and Drug Resistance
Volume
Volume 19
Pages
1–16
Publication date
1 February 2026
Language
EN