Clinical Value of Limb-Lead R-Wave Amplitude in Predicting Cardiac Rupture After Acute Anterior Myocardial Infarction Undergoing PCI

Background: Cardiac rupture remains a fatal complication of acute anterior myocardial infarction (AAMI), especially in the high-risk subset that develops left ventricular aneurysm (LVA). This study aimed to evaluate the predictive value of the average R-wave voltage in the electrocardiographic limb leads (AVRE) for cardiac rupture in this specific AAMI with LVA population. Methods: We conducted a retrospective, single-center study of 249 AAMI patients undergoing primary PCI, comparing 63 with cardiac rupture (CR group) to 186 without (Control group). Key inclusion criteria were typical chest pain and ST-segment elevation on ECG. AVRE was measured on admission ECG. Multivariate logistic regression and ROC curve analysis were used to identify independent predictors and assess the predictive performance of AVRE. Results: Patients with cardiac rupture had a significantly lower average limb-lead R-wave voltage (AVRE) than controls (2.33 vs 3.33 mV, p