Nano-Enabled Therapeutics: Novel Strategies for Preeclampsia Treatment
Abstract
Preeclampsia (PE), a pregnancy-specific disorder characterized by hypertension and placental dysfunction, remains a leading cause of maternal and fetal morbidities worldwide. Recent advances in nanomedicine offer promising therapeutic strategies by targeting placental pathologies. Studies have demonstrated that in PE mouse models, the regulation of key disease-related genes (such as sFlt1 and VEGF) using siRNA- or mRNA-loaded carriers (eg, lipid nanoparticles, exosomes, or elastin-like polypeptides) can effectively alleviate PE symptoms. This review summarizes the progress in nanoparticle-based therapies for PE, discusses challenges such as scalability and clinical translation, and highlights the potential of nanomedicine to revolutionize PE management.
Fields of Study & Subjects
Pregnancy and preeclampsia studies
Reproductive System and Pregnancy
Preterm Birth and Chorioamnionitis
Publication details
- Journal / source
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Volume
- Volume 21
- Pages
- 1–14
- Publication date
- 1 January 2026
- Language
- EN