Management of Informal Caregiver Burden in a Case of Primary Cerebral Ewing’s Sarcoma: A Case Report

Background: Primary cerebral Ewing’s sarcoma is a rare and aggressive brain tumor with poor prognosis and limited treatment guidelines. This case describes the assessment and management of caregiver burden for the patient’s sister during the rehabilitation pathway. Case Presentation: A 57-year-old man with primary cerebral Ewing’s sarcoma deteriorated rapidly and required care from his 50-year-old sister. Her burden was assessed using the Zarit Burden Interview (ZBI) and the Caregiver Reaction Assessment Scale (CRAS). Interventions included psychological support, relaxation techniques, respite scheduling, and regular multidisciplinary meetings. These efforts reduced caregiver strain and improved perceived support. Patient-Reported Experience Measures (PREMs) showed high satisfaction with inpatient care but revealed gaps in community care continuity. Conclusion: Caregiver-centred models and improved transitional care should be incorporated into the treatment of rare, high-burden neurological conditions. Plain Language Summary: Informal caregivers of patients with rare neurological cancers face significant emotional and physical burden, which can undermine both the quality and sustainability of home-based care.Early systematic assessment of caregiver strain using validated tools (eg, ZBI, CRAS) can guide timely psychological and rehabilitative interventions.Multidisciplinary rehabilitation planning that actively includes the caregiver as a partner improves care coordination and enhances caregiver coping capacity.Providing structured emotional support and caregiver training enhances adherence to rehabilitation protocols and supports long-term functional outcomes for both patients and caregivers. Keywords: caregiver burden, informal caregiving, multidisciplinary care, neuro-oncological rehabilitation, primary cerebral Ewing’s sarcoma, psychological support