The Joint Effect of C-Reactive Protein and Fibrinogen in Predicting Intracranial Hypertension of Cerebral Venous Sinus Thrombosis Patients

Purpose: Intracranial hypertension is the most common symptom of cerebral venous sinus thrombosis. Recent studies have indicated that both the coagulation and inflammation systems play roles in the occurrence and development of cerebral venous sinus thrombosis. Therefore, this study aimed to explore the individual and combined effects of coagulation-related biomarker [fibrinogen (FIB)] and inflammation-related biomarker [C-reactive Protein (CRP)] in predicting intracranial hypertension. Patients and Methods: We retrospectively and consecutively included 157 cerebral venous sinus thrombosis patients, who were divided into four groups according to the cut-offs of CRP and FIB by the receiver operating characteristics curves: low CRP low FIB, high CRP low FIB, low CRP high FIB and high CRP high FIB. Logistic regression models were used to compute the odds ratios and 95% confidence intervals for intracranial hypertension across the four subgroups. Results: Cerebral venous sinus thrombosis patients with intracranial hypertension had much higher CRP and FIB levels than those without intracranial hypertension did (all P