Application Effect of Colostrum Oral Immunotherapy in the Early Stage of Mechanical Ventilation for Very Low Birth Weight Preterm Infants

Objective: This study aims to evaluate the impact of C-OIT on outcomes of VLBW preterm infants during early mechanical ventilation. Methods: A retrospective analysis was conducted on preterm infants with birth weight 0.05), ensuring comparability. The intervention group exhibited shorter mechanical ventilation duration and hospital stay compared to the control group. Post-treatment scores and total scores of PIOFRA were higher in the intervention group. The intervention group showed shorter initiation time for oral feeding, complete oral feeding time, and birth weight recovery time. Levels of secretory immunoglobulin A (sIgA) and lactoferrin in airway secretions and urine were elevated in the intervention group post-treatment. Post-intervention body weight, head circumference, and body length were greater in the intervention group. The incidence of adverse reactions was significantly lower in the intervention group. All intergroup differences were statistically significant (P