When and How Grid-Based Information Management for VTE Prevention: Boundary Conditions and Configurational Pathways from a Mixed-Methods Study

Background: Venous thromboembolism (VTE) is a significant cause of preventable morbidity and mortality among hospitalized patients. Although grid-based information management systems have shown effectiveness in VTE prevention, the boundary conditions and configurational pathways leading to optimal outcomes remain unclear. Objective: To investigate the impact mechanism of grid-based information management on VTE prevention effectiveness, identify boundary conditions of moderating effects, and explore configurational pathways leading to high prevention outcomes. Methods: A mixed-methods study design was employed. A total of 119 hospitalized patients from Affiliated Hospital of North Sichuan Medical college were enrolled between January and December 2024, with 58 patients in the control group (traditional management) and 61 in the intervention group (grid-based information management). The Johnson-Neyman (J-N) technique was used to identify the boundary conditions of nurses' VTE knowledge and departmental collaboration on intervention effectiveness. Fuzzy-set qualitative comparative analysis (fsQCA) was employed to identify configurational pathways leading to high VTE prevention outcomes. Results: The intervention group demonstrated significantly higher VTE risk assessment completion rates (86.9% vs 63.8%, absolute difference 23.1%, 95% CI 8.7-37.5%, P