Cychlorphine (N-Propionitrile Chlorphine): An Emerging Benzimidazolone Synthetic Opioid and Its Implications for Overdose Recognition and Management

Journal of Pain Research 2026 Open access

Read full text
Authors: Robert B. Raffa, Frank Breve, Joseph V. Pergolizzi, Eugene Vortsman, Giustino Varrassi
DOI: 10.2147/jpr.s620907
Cited by: 1

Abstract

Robert B Raffa,1,2 Frank Breve,3 Joseph V Pergolizzi Jr,2,4 Eugene Vortsman,5 Giustino Varrassi61School of Pharmacy, Temple University (Emeritus), Philadelphia, PA, USA; 2Research and Development, Enalare Therapeutics, Mullica Hill, NJ, USA; 3Clinical Pharmacy, Mid Atlantic PharmaTech Consultants, Ventnor City, NJ, USA; 4Anesthesiology, NEMA Research, Naples, FL, USA; 5Emergency Department, Long Island Jewish Medical Center at Northwell Health, New York, NY, USA; 6VIBRO, Fondazione Paolo Procacci, Roma, ItalyCorrespondence: Robert B Raffa, Email robert.raffa@gmail.com

Fields of Study & Subjects

Poisoning and overdose treatments Opioid Use Disorder Treatment Pain Management and Opioid Use

Publication details

Journal / source
Journal of Pain Research
Publisher
Informa UK Limited
Volume
Volume 19
Pages
1–3
Publication date
1 July 2026
Language
EN