Comfort and Ocular Surface Impact of Verofilcon A Daily Disposable Contact Lenses in Satisfied Senofilcon A Daily Disposable Lens Wearers: A Prospective Non-Interventional Study

Purpose: To evaluate quality of life, comfort, and vision in long-term satisfied wearers of Senofilcon A daily disposable contact lens (SA) contact lenses after switching to Verofilcon A daily disposable contact lenses (VA), and to assess ocular surface parameters using an objective diagnostic platform C.DIAG (Quantel Medical, a brand of Lumibird, Clermont-Ferrand, France), a multimodal imaging platform for tear film assessment. Methods: This was a prospective, single-center, non-interventional study including 30 participants aged 20-40 years, all satisfied SA wearers. After 14 ± 2 days of vA wear, participants completed the CLDEQ-8 questionnaire and rated comfort and vision using a visual analog scale (VAS). Objective ocular surface assessments were performed using C.diag, including non-invasive tear break-up time (NIBUT), interferometry, blink analysis, and tear meniscus height. Statistical analysis was performed using paired Student's t-tests to compare subjective outcomes before and after the lens switch. Statistical significance was defined as p < 0.05. Results: The mean CLDEQ-8 score with va was 6.33 ± 2.82, with 56.7% of participants categorised as "excellent." VAS scores for vision and comfort with va were 87.3 ± 9.4 and 86.6 ± 10.8, respectively. No statistically significant deterioration in tear film parameters was observed after switching lenses (p > 0.05). NIBUT measurements were 11.5 ± 4.4 seconds (od) and 11.8 ± 4.3 seconds (os), with stable interferometry scores and consistent tear meniscus height observed. Conclusion: VA daily disposable contact lenses provided high levels of subjective comfort and stable objective ocular surface parameters in previously satisfied daily disposable lens wearers. The C.DIAG device enabled standardized and non-invasive tear film analysis during contact lens wear. Further randomized and long-term studies are warranted to confirm these findings.