OVERNIGHT OCCLUSIVE TOPICAL APPLICATION OF HIGH-CONCENTRATION 35 KDA HYALURONIC ACID FRAGMENTS FOR FACIAL ERYTHEMA AND SUBCUTANEOUS FAT: A CASE SERIES

Background:The naked mole rat (NMR) exhibits an exceptionally high concentration of hyaluronan (HA) in the skin and subcutaneous tissues, minimal subcutaneous fat accumulation, and a low incidence of inflammatory skin conditions. These features suggest a potential role for high-concentration HA in regulating cutaneous inflammation and adipose-related facial appearance. Methods:This exploratory case series included five adults seeking non-invasive improvement of facial erythema and localized subcutaneous fat. A 10% formulation of 35 kDaHA fragments was applied to the entire face under occlusive conditions overnight once every two days for a total of five applications. Facial subcutaneous fat appearance, inflammatory erythema, skin radiance, and nasal alar pore condition were assessed at baseline, after the first application, and after the fifth application using a standardized 0-10 numerical rating scale (NRS). Results: All participants demonstrated consistent reductions in facial subcutaneous fat appearance and inflammatory erythema, with visible improvement observed after the first overnight application and further enhancement following repeated treatment. Skin radiance improved and nasal alar pore enlargement was attenuated in all cases. No local or systemic adverse events were reported.