MECHANISTIC STUDY OF MELATONIN: A SYSTEMATIC REVIEW

International Journal of Advanced Research 2026 Open access

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Authors: B. Aliyu, N.S. Kangiwa and U.Z. Umar B. Aliyu, U. Z. Umar
DOI: 10.21474/ijar01/22678
Cited by: 0

Abstract

Background: Melatonin, a neurohormone synthesized primarily in the pineal gland, plays a central role in regulating circadian rhythms and sleep-wake cycles. Purpose: Beyond its chronobiotic functions,melatonin exhibits potent a ntioxidant,anti inflammatory, immunomodulatory,and oncostatic proper ties.This review explores the multifaceted molecular and cellular mecha nisms of melatonin across physiological and pathological conditions. Methods: A systematic review following PRISMA guidelines was conducted using databases including PubMed, Scopus, Web of Science, and Google Scholar. Studies from 1990 to 2024 focusing on mechanisti c insights were included.

Fields of Study & Subjects

Circadian rhythm and melatonin melanin and skin pigmentation Impact of Light on Environment and Health

Publication details

Journal / source
International Journal of Advanced Research
Volume
14
Issue
01
Pages
1431–1433
Publication date
31 January 2026
Language
EN