CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE PROSTHETIC HIP INFECTION FOLLOWING A PELVIC PRESSURE ULCER: THERAPEUTIC VALUE OF CEFTAZIDIME AVIBACTAM

Periprosthetic joint infections (PJI) after total hip arthroplasty (THA) remain a major cause of morbidity, particularly when caused by multidrug-resistant Gram-negative bacteria. Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a critical therapeutic challenge, with limited antimicrobial options and poor clinical outcomes. We describe the case of an elderly woman with a complicated pelvic pressure ulcer infected by CRKP who subsequently developed a chronic PJI of a recently implanted hip prosthesis caused by the same strain, strongly suggesting hematogenous spread from the remote infectious focus.This case illustrates the diagnostic complexity and therapeutic difficulties associated with CRKP PJI and highlights the successful use of ceftazidime avibactam after failure of conventional therapies, supporting its role as a valuable treatment option for severe prosthetic joint infections due to carbapenem resistant Enterobacterales.