Salivary gland acinar cell carcinoma: Long-term treatment experience

Malignant tumors of the salivary glands are a rare type of neoplasm in the head and neck region. Adenoid cystic carcinoma of the salivary gland is characterized by a high propensity for perineural invasion and frequent local and distant recurrences. The primary treatment for localized adenoid cystic carcinoma of the salivary gland is surgical removal of the tumor, while radiation therapy is considered the most effective for local recurrences. However, modern treatment methods for recurrent or metastatic adenoid cystic carcinoma of the salivary gland do not always yield the expected results. The disease is rare, which has led to limited understanding of its etiopathogenesis; however, several genetic mutations and biomarkers associated with the onset and/or progression of adenoid cystic carcinoma of the salivary gland have been identified. The discovery of these mutations has made targeted precision therapy possible, with ongoing research and development in this area. This article presents a case history of long-term (25 years) observation and successful treatment of adenoid cystic carcinoma of the salivary gland, which was accompanied by multiple progressions and adjustments in systemic therapy based on the genetic characteristics of the tumor. The aim of this publication is not only to present a rare clinical observation but also to highlight current issues, modern approaches, and emerging trends in the diagnosis and treatment of adenoid cystic carcinoma of the salivary gland.