Features of clinic and therapy of combined dermatoses in patients with a comorbid background

The article discusses the causes of occurrence and the clinical features of chronic dermatoses complicated by mycotic infections, which occur in patients with comorbid backgrounds. It presents data from domestic and international literature on the epidemiology and characteristics of the course of combined dermatoses. Recent scientific studies indicate obesity and metabolic syndrome as aggravating factors in the progression of psoriasis, allergodermatoses, and mycoses. The accompanying somatic problems worsen the course of skin diseases, contribute to their chronicity, hinder effective diagnosis and treatment, reduce patients’ quality of life, and may lead to an unfavorable prognosis. At the same time, a patient with metabolic syndrome may simultaneously present several skin conditions, each influencing the course of the others, which exacerbates the clinical picture and increases the severity of the disease. Warm, moist environments and friction in skin folds promote colonization of eruptions in psoriasis and allergodermatoses by bacteria, fungi, or pathogenic yeasts, leading to eczematization with exudation and erosion formation, often resistant to therapy. Particular emphasis is placed on the diagnosis and treatment of this group of patients, as fold lesions pose difficulties, especially against the background of comorbidities. Effective treatment requires a comprehensive assessment of clinical manifestations and the presence of accompanying diseases to prescribe combination therapies, as well as preventive measures to reduce the risk of secondary infections. The article also includes our clinical observations of patients with a comorbid background (obesity, diabetes mellitus) suffering from chronic dermatoses complicated by mycotic infections. It is demonstrated that the use of Akriderm GK cream (0.05% clotrimazole + 0.1% gentamicin + 1% betamethasone) and Acrimicole cream (2% sertaconazole cream) achieves a positive effect in treating dermatitis complicated by fungal infections in the context of comorbidities.