Survival Under Siege: The Effect of Nutritional and Environmental Stress on Persistence in Klebsiella pneumoniae and Proteus mirabilis
Abstract
Persister cells pose a critical challenge in treating chronic and recurrent infections. This study systematically evaluated the impact of diverse stress conditions including acidic pH, osmotic pressure, nutrient and amino acid starvation, phosphate modulation, and long-term environmental exposure on persister cell formation and resistance evolution in Klebsiella pneumoniae and Proteus mirabilis. Short-term stress assays revealed species-specific patterns: Klebsiella pneumoniae exhibited lowest persister levels at pH 3 and under hyperosmotic stress (0.8 M sodium chloride (NaCl),
Fields of Study & Subjects
Bacterial Genetics and Biotechnology
Bacterial biofilms and quorum sensing
Antibiotic Resistance in Bacteria
Publication details
- Journal / source
- Archives of Pharmaceutical Sciences Ain Shams University
- Volume
- 0
- Issue
- 0
- Publication date
- 10 January 2026
- Language
- EN