Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio as a Marker of Disease Severity and Prognosis in Guillain-Barre Syndrome

Abstract Background: Guillain-Barre syndrome (GBS) is an acute immune mediated inflammatory demyelinating polyradiculoneuropathy. It is considered by rapid regressive ascending weakness and diminished or absent deep tendon reflexes. The purpose of the study was to evaluate the platelet to lymphocyte ratio (PLR) and the neutrophil to lymphocyte ratio (NLR) as prognostic biomarkers in GBS patients. Methods: The present prospective cohort study conducted at Kobry El- kobba Military Medical Complex, performed on 92 patients divided into two groups: 46 patients in GBS group and 46 patients in control group. Results: There was statistically significant increase in inflammatory markers in GBS patients than control regarding Erythrocyte Sedimentation Rate (ESR), CRP, NLR 1st and PLR 1st on admission. On discharge, the mean of NLR was 2.99±0.7 and the mean of PLR was 121.88±11.8 Conclusions: We concluded from our study that: NLR, PLR, ESR and C-Reactive Protein (CRP) might be a promising marker in GBS regardless of infection, High NLR may be correlated with a slow recovery and indicative of GBS severity, NLR and PLR was higher in AMSAN subtype with most severe clinical presentation and poor functional outcome, NLR had higher sensitivity and specificity than PLR in prediction of GBS severity.