Comparing Dexmedetomidine and Magnesium Sulphate for Blunting Sympathetic Response of Extubation in Controlled Hypertensive Patients: A Randomized Comparative Trial.

Background: In patients with hypertension, tracheal extubation frequently results in a sympathetic stress response that is marked by tachycardia and hypertension, which can be severe and dangerous. This study examined the effectiveness of magnesium sulphate and dexmedetomidine in reducing this hemodynamic reaction in patients with controlled hypertension immediately following extubation .Methods: At the Maadi Armed Forces Medical Complex and Armed Forces College of Medicine Hospital in Egypt, a prospective, randomized, single-blind comparative study was carried out. Sixty-four adult patients with controlled hypertension who were scheduled for elective surgery were split into two groups at random: intravenous magnesium sulphate (30 mg/kg) or dexmedetomidine (0.5 µg/kg) for ten minutes before to extubation. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and heart rate (HR) were measured at baseline, during, and after extubation. Both the postoperative Visual Analogue Scale (VAS) scores and the time to reach a modified Aldrete score of ≥9 were evaluated. Results: The dexmedetomidine group demonstrated significantly lower SBP, DBP, and MAP during and after extubation compared to the magnesium sulphate group (p