Impacts of naringin treatment on type 2 diabetic rats

Diabetes endangers human health, naringin (NAR), a citrus-derived flavonoid, possesses antioxidant, anti-inflammatory, and antidiabetic properties. This study aimed to address the biochemical mechanisms of hepatic improvement after NAR treatments in rats with type 2 diabetes mellitus (T2-DM). Four groups were used in the current study as follows: the first group was the negative control, the second was the T2-DM, the third was the T2-DM/metformin (MTF) (200 mg/kg), and the fourth group was the T2-DM/NAR (100 mg/kg). All treatments were performed by oral garage daily for a month. At the end of the experiment, all body weight changes were recorded. Biochemical and molecular investigations were performed in the different groups. The results showed that the treatment with NAR led to decreased hepatic oxidative stress and modulated hepatic insulin‑PI3K/Akt signaling pathway. NAR ameliorates hyperglycemia, dyslipidemia, oxidative stress, and tissue damage in T2-DM rats, suggesting its potential as a natural therapeutic candidate for managing T2-DM.