Effect of Adipose Derived Stem Cells on Split Thickness Skin Graft Taking in Burn Wounds Management

ABSTRACT Background: Burn injuries are a major global health burden, especially in low- and middle-income countries. Split-thickness skin grafts (STSGs) are the standard treatment for deep burns but are associated with some complications such as graft loss, scarring, and poor aesthetic outcomes. Adipose-derived stem cells (ADSCs) have regenerative and angiogenic properties that may improve graft performance. This study aims to evaluate the efficacy of ADSCs in enhancing graft take, reducing complications, and improving aesthetic outcomes in burn management. Methods: A randomized clinical study included 60 patients complained from post burn raw areas and were managed by STSG, the patients were divided into two groups: Group I (STSG + ADSCs) and Group II (STSG only). ADSCs were prepared from autologous fat and applied to the graft bed and donor site in Group I. Assessment of the outcomes included graft take rate, healing time, rate of complications, and scar quality using the Patient and Observer Scar Assessment Scale (POSAS) over a 6-month follow-up. Results: Group I showed significantly better graft take (Excellent graft take was 56.7% in group I vs. 20% in group II, p