Repurposed drug in nanofiber for wound healing : A Synergistic Approach to Next-Generation Wound Healing

wound healing is a multifaceted and active biological process which is crucial for restoring the integrity of the skin after injury. Despite advancements in clinical practice, chronic and delayed wound healing still represent a major clinical challenge, particularly in patients with chronic conditions such as diabetes. This review explores recent advances in wound healing therapies that integrate drug repurposing strategies with electrospinning technologies. Drug repurposing accelerates therapeutic development by identifying new clinical indication for existing drugs with established safety profile, while electrospinning enables the fabrication of nanofibrous scaffolds that closely mimic the extracellular matrix, and enable controlled and localized drug delivery. The reviewed evidence indicates that these systems can enhance antimicrobial activity, modulate inflammation, and promote tissue regeneration. Overall, this review aims to provide a comprehensive and forward-looking perspective on the potential of repurposed drug-loaded nanofibers as a next generation wound healing therapy.This review is based on a structured literature search of PubMed, Scopus, and Web of Science (2010-2025).