Association of Angiopoietin-Like 3 and Apolipoprotein B Gene Polymorphisms with Coronary Artery Disease

Background: Coronary artery disease (CAD) as a leading cause of mortality, is highly prevalent in Egypt. While traditional risk factors are well-established, genetic predispositions, particularly in lipid-regulating genes like angiopoietin-like 3 (ANGPTL3) , apolipoprotein B (APOB), are critical determinants of individual susceptibility. This study aimed to evaluate the relationship of ANGPTL3 (rs1748195) ,POB (rs562338) polymorphisms with CAD risk among Egyptian population.Methods: We included 112 subjects in this case-control study: 56 patients with angiographically confirmed CAD, 56 age- sex-matched healthy controls. All participants underwent detailed clinical, biochemical profiling. Genotyping for the two polymorphisms was performed using tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR).Results: Compared to controls, CAD patients exhibited a significantly worse metabolic profile, including higher BMI, fasting blood glucose, HbA1c, total cholesterol, triglycerides, and LDL-C, alongside lower HDL-C (all p