Daily Routine Exercise and Inhibition of Cancer Cell Growth: A Systematic Review

Purpose: To evaluate the effects of daily routine physical therapy-guided exercises, including morning walks, aerobic training, resistance exercises, and flexibility routines, on the inhibition of cancer cell growth and associated physiological mechanisms.Methods: A thorough search of PubMed, Scopus, Web of Science, and Google Scholar databases was performed to retrieve articles published within the past ten years.Eligible studies were randomized controlled trials, clinical trials, and experimental research that investigated the effect of structured exercise intervention on cancer patients or preclinical models.Primary outcomes assessed included tumor progression, apoptosis, immune modulation, recurrence rates, survival outcomes, and quality of life.Methodological quality and risk of bias were evaluated using the modified Cochrane RoB 1 tool.Results: A total of 25 studies were selected based on inclusion criteria.Morning walks and aerobic exercise showed evidence of a beneficial effect on cardiorespiratory fitness, reduced systemic inflammation, and increased natural killer (NK) cell activity.Whereas resistance training stimulated apoptosis in cancerous cells and maintained lean mass, flexibility and mobility-centered routines also alleviated fatigue and increased functional independence.Conclusion: Daily routine exercise prescribed within physical therapy practice, including morning walks, aerobics, resistance training, and flexibility exercises, plays a vital role in inhibiting cancer cell growth, enhancing functional capacity, and improving quality of life.