Effectiveness of Trans-Arterial Chemoembolization (TACE) for Hepatocellular Carcinoma on Follow-Up Triphasic CT of the Liver

Purpose: IPF is a chronic, progressive fibrosing interstitial lung disease (ILD) of unknown etiology.HRCT plays a central role in the non-invasive identification of IPF.This study aims to evaluate the diagnostic accuracy and predictive value of HRCT in detecting IPF in patients with clinical suspicion of the disease.Methods: A cross-sectional descriptive study was conducted involving 68 patients with suspected IPF at a radiology diagnostic center in Islamabad.All patients underwent HRCT scans, which were assessed for typical IPF patterns including honeycombing, GGO, and reticulation.Data were analyzed using SPSS v25.0.Diagnostic metrics were computed, and statistical tests, including logistic regression and ROC curve analysis, were applied.Results: HRCT confirmed IPF in 91.2% of patients.Honeycombing was observed in 55.9%, reticular patterns in 60.3%, and GGO in 51.5% of patients.Patchy GGO was the most prevalent GGO subtype (22.1%).Honeycombing alone yielded a specificity of 100%, sensitivity of 61%, and PPV of 1.00.The ROC curve for honeycombing presented an AUC of 0.806 (95% CI: 0.687-0.926,p=0.014).Logistic regression identified honeycombing (p=0.004),GGO (p = 0.021), and reticulation (p=0.010) as significant predictors of IPF.Conclusion: HRCT demonstrates high diagnostic accuracy in confirming IPF, especially through the identification of honeycombing, which showed excellent specificity and PPV.Although honeycombing alone is not sufficiently sensitive, its diagnostic utility is significantly enhanced when combined with GGO and reticular patterns.