A 15-year Follow-up of Persistent Pulmonary Lesions after Silicone Removal in a Patient with Silicon-induced Autoimmune/Inflammatory Syndrome

Internal Medicine 2026 Open access

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Authors: Natsumi Watanabe, Yoshinori Tanino, Takefumi Nikaido, Yuki Sato, Ryuichi Togawa, Xintao Wang, Naoko Fukuhara, Tetsuya Egawa, Takahiro Kumanaka, Ryutaro Tanaka, Kentaro Kazama, Koshi Saito
+13 more Rina Harigane, Ryuki Yamada, Riko Sato, Hikaru Tomita, Mami Rikimaru, Takashi Umeda, Yasuhito Suzuki, Junpei Saito, Kenya Kanazawa, Hiroyuki Suzuki, Yuko Hashimoto, Akira Hebisawa, Yoko Shibata
DOI: 10.2169/internalmedicine.5944-25
Cited by: 1
References: 24

Abstract

A 65-year-old woman with a history of silicone breast implantation was admitted to our hospital with abnormal chest shadows. Although the implants had already been removed, chest CT revealed diffuse ground-glass opacities in both lungs. Thoracoscopic lung biopsy revealed non-necrotizing epithelioid granulomas and silica-phagocytic macrophages, leading to a diagnosis of silicone-implant-associated autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Over a follow-up period of more than 15 years without treatment, the ground-glass opacities improved only slightly. We herein present the longest follow-up chest CT findings of silicone implant-associated ASIA.

Fields of Study & Subjects

Breast Implant and Reconstruction Corneal surgery and disorders Dental Implant Techniques and Outcomes

Publication details

Journal / source
Internal Medicine
Publisher
Japanese Society of Internal Medicine
Volume
65
Issue
15
Pages
2130–2135
Publication date
1 January 2026
Language
EN