Treat-and-repair Strategy for Atrial Septal Defect with Eisenmenger Syndrome due to Pulmonary Arterial Hypertension

Internal Medicine 2026 Open access

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Authors: Muneyuki Kadota, Shusuke Yagi, Akagi Satoshi, Shingo Kasahara, Issei Yagi, Shingo Hashimoto, Yoshihito Saijo, Yutaka Kawabata, T Takahashi, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi
+3 more Hirotsugu Yamada, Takeshi Soeki, Masataka Sata
DOI: 10.2169/internalmedicine.5948-25
Cited by: 0
References: 12

Abstract

A 53-year-old man with Eisenmenger syndrome (ES), caused by a large secundum atrial septal defect (ASD) and severe pulmonary arterial hypertension (PAH), showed a marked hemodynamic improvement following an escalation of PAH-specific therapy. Surgical ASD closure using a fenestrated patch was successfully performed after a significant reduction in both the patient's pulmonary pressure and vascular resistance. This case highlights the potential utility of the "treat-and-repair" strategy in patients with ES and severe PAH, who exhibit a favorable response to medical therapy, resulting in both a symptomatic and hemodynamic improvement.

Fields of Study & Subjects

Cardiovascular and Diving-Related Complications Congenital Heart Disease Studies Pulmonary Hypertension Research and Treatments

Publication details

Journal / source
Internal Medicine
Volume
65
Issue
17
Pages
2346–2351
Publication date
14 January 2026
Language
EN