Eosinophilic Granulomatosis with Polyangiitis that Manifested after Administration of Benralizumab in a Patient with Refractory Recurrent Bronchial Asthma

Internal Medicine 2026 Open access

Read full text
Authors: Ukyo Yamamoto, Yuki Oba, Tetsuro Rikihisa, Shoya Taniguchi, Hiroki Mizuno, Akinari Sekine, Masayuki Yamanouchi, Eiko Hasegawa, Tatsuya Suwabe, Meiyo Tamaoka, Hisashi Takaya, Kei Kono
+4 more Kenichi Ohashi, Takehiko Wada, Naoki Sawa, Yoshifumi Ubara
DOI: 10.2169/internalmedicine.6141-25
Cited by: 1
References: 9

Abstract

A 73-year-old woman with bronchial asthma presented with a rash and peripheral neuropathy. Since 21 years old, her asthma had been treated with glucocorticoids. Benralizumab had been introduced six years ago, and glucocorticoids were discontinued one year later. Bronchial asthma had been in remission for 5 years. On admission, urinalysis findings were mildly abnormal, myeloperoxidase-specific antineutrophil cytoplasmic antibody was positive, and eosinophilia was observed. A renal biopsy showed signs of mild necrotizing vasculitis with eosinophilia. Eosinophilic granulomatosis with polyangiitis (EGPA) was diagnosed. Benralizumab was discontinued, glucocorticoids were restarted, and mepolizumab was administered. Since then, the EGPA and asthma have not recurred.

Fields of Study & Subjects

Vasculitis and related conditions Eosinophilic Disorders and Syndromes Eosinophilic Esophagitis

Publication details

Journal / source
Internal Medicine
Publisher
Japanese Society of Internal Medicine
Volume
65
Issue
10
Pages
1372–1376
Publication date
14 May 2026
Language
EN