Eosinophilic Bronchiolitis Diagnosed by a Transbronchial Lung Cryobiopsy and Successfully Treated with Biologic Agents: A Report of Two Cases and Literature Review

Internal Medicine 2026 Open access

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Authors: Katsuhiro Itogawa, Masako Amano, Daisuke Nakatani, Hiroki Ohta, Kenji Kusano, Tomohiro Oba, Rie Kawabe, Hideaki Yamakawa, Shintaro Sato, Keiichi Akasaka, Akiko Adachi, Tamiko Takemura
+1 more Hidekazu Matsushima
DOI: 10.2169/internalmedicine.6267-25
Cited by: 0
References: 26

Abstract

Eosinophilic bronchiolitis (EB) is a rare airway disease characterized by eosinophilic bronchiolar inflammation. We herein report two cases of EB diagnosed by a transbronchial lung cryobiopsy (TBLC), a less invasive diagnostic procedure than a surgical biopsy. Two patients with a history of refractory asthma responded to treatment with oral corticosteroids and biologic agents. To our knowledge, these are among the first reported cases of EB that were successfully managed with dupilumab and benralizumab. These cases underscore the diagnostic utility of TBLCs and suggest the potential use of biologic agents as corticosteroid-sparing options for EB.

Fields of Study & Subjects

Asthma and respiratory diseases Eosinophilic Disorders and Syndromes Eosinophilic Esophagitis

Publication details

Journal / source
Internal Medicine
Volume
65
Issue
18
Pages
2465–2470
Publication date
9 February 2026
Language
EN