Atypical Cogan's Syndrome Is Common among Japanese Patients: A Case Report and Literature Review in Japan
Abstract
We report the case of a 55-year-old Japanese woman who presented with fever, headache, vertigo, sensorineural hearing loss, and scleritis, leading to a diagnosis of Cogan's syndrome (CS). Her hearing acuity recovered to previous levels after high-dose glucocorticoid treatment, despite seven weeks having passed since the onset. We reviewed 30 adult cases of Japanese CS using PubMed and Ichushi-Web. We identified several clinical features of Japanese patients with CS, including an older age of onset, less interstitial keratitis, more frequent fever and headache, elevated inflammatory marker levels, and a higher prevalence of large-vessel vasculitis, compared with studies on Caucasians.
Fields of Study & Subjects
Ocular Diseases and Behçet’s Syndrome
Vasculitis and related conditions
Otitis Media and Relapsing Polychondritis
Publication details
- Journal / source
- Internal Medicine
- Volume
- 65
- Issue
- 18
- Pages
- 2501–2509
- Publication date
- 9 February 2026
- Language
- EN