Fluoroquinolones Inhibit, while β-Lactams Fail Against Biofilm-Producing Bacteria Isolated from Paediatric Syrups

Background: Paediatric syrups are sugar-rich solutions widely preferred in paediatric healthcare due to their palatability, although they are highly prone to microbial contamination. Of particular concern is the presence of biofilm-producing microorganisms; existing studies have focused on contamination while overlooking the enhanced resistance mechanisms conferred by biofilm formation. This study aimed to determine the antibiogram profile of bacterial isolates from commonly prescribed paediatric syrups administered by caregivers to patients at selected healthcare centers.Materials and Methods: A total of 392 syrup sample swabs were collected from hospitals and community sources. Bacterial isolation and identification were performed using standard microbiological methods. Biofilm production was evaluated using the test-tube method, and antibiotic susceptibility was determined via the disk diffusion method.Results: Bacterial counts ranged from 3.0±2.0×10³ to 10.7±3.05×10³ CFU/mL, with community samples showing the highest counts. Bacterial isolates identified included Proteus vulgaris, with the highest frequency of occurrence (18.75%) > Streptococcus agalactiae, Klebsiella pneumoniae, Acinetobacter baumannii (12.59%) > Pseudomonas aeruginosa, Arthrobacter agilis, Enterococcus faecium, Enterobacter cloacae, Escherichia coli (6.25%). All isolates produced biofilms significantly different (p