Protective Role of Glibenclamide and Magnesium Sulfate in Fructoseinduced Type 2 Diabetes Mellitus
Abstract
INTRODUCTION: This study aimed to evaluate the protective effects of glibenclamide and magnesium sulfate in fructose-induced type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: An experimental T2DM model was established in female Sprague Dawley rats using a 20% fructose solution for 12 weeks. The effects of glibenclamide and magnesium sulfate were assessed on glycemic control, oxidative stress, lipid profile, and tissue macro- and trace-element levels. Biochemical parameters were determined spectrophotometrically, and data were analyzed using one-way ANOVA in SPSS (version 22). RESULTS: Treatment with glibenclamide and magnesium sulfate significantly (p
Fields of Study & Subjects
Diet
Metabolism
and Disease
Diabetes
and Cancer
Microbial Metabolites in Food Biotechnology
Publication details
- Journal / source
- Current Pharmaceutical Biotechnology
- Publisher
- Bentham Science Publishers Ltd.
- Volume
- 27
- Publication date
- 12 January 2026
- Language
- EN