GCN2 in Cancer: Molecular Mechanisms to Therapeutic Potential
Abstract
Virtually every mammalian cell contains the cytoplasmic protein kinase General Control Non-depressible 2 (GCN2), which allows cells to cope with stresses such as nutrient shortage. While GCN2 is not essential for normal cells, in many cancers GCN2 assumes a pivotal role, becoming indispensable for cell growth and survival. This has spurred significant interest in GCN2 as a promising target for anticancer therapies. In this review, we give an overview of the known links between GCN2 and cancer.
Fields of Study & Subjects
Synthesis and Characterization of Heterocyclic Compounds
Bioactive Compounds and Antitumor Agents
Publication details
- Journal / source
- Current Cancer Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Volume
- 26
- Issue
- 3
- Pages
- 269–288
- Publication date
- 1 March 2026
- Language
- EN