Hippophae rhamnoides: Way to Ameliorate Depressive Augury by Cyanocobalamin

INTRODUCTION: Vitamins are essential for maintaining wellness since they are involved in several distinct physiological functions. In addition to being necessary for the methylation cycle and the creation of monoamine oxidase, vitamin B complex is also required for deoxyribonucleic acid synthesis, phospholipid preservation, and repair. Vitamin B deficiency or excess may affect dementia, cognitive decline, and memory. Deficits in these vitamins, particularly B12 (cobalamin, or vitamin B12), are therefore strongly linked to depression. Cyanocobalamin is used to assist in managing deficiencies, available as nasal spray, injection, and oral supplements. Chemically, cyanocobalamin is classified as a "corrinoid," which refers to a cobalt complex that may crystallize. The FDA of the United States has licensed cyanocobalamin for the treatment of Helicobacter pylori infection, atrophic gastritis, malabsorption, depression, autoimmune anemia, and other disorders. METHOD: Information from in vivo, in silico, and clinical trials was gathered for this review from sources such as Google Scholar, ScienceDirect, and PubMed. The antidepressant properties of vitamin B12 derived from Hippophae rhamnoides were the primary focus. RESULTS: Research indicates that cyanocobalamin modulates inflammation, oxidative stress, and serotonin and dopamine pathways. It enhances treatment responsiveness and reduces depression symptoms when used alongside conventional antidepressants. DISCUSSION: Vitamin B12's significance in energy metabolism and antioxidant defense complements its neurochemical benefits. The natural cyanocobalamin source, Hippophae rhamnoides, offers a unique treatment approach that may improve mood and protect neurons. CONCLUSION: Based on these studies, it was concluded that vitamin B12 may delay depression onset and enhance the effectiveness of antidepressants. Other vitamins, such as vitamin B6 (pyridoxine) and B9 (folate), also influence depression. However, in this study, we first focused on the effect of vitamin B12 from Hippophae rhamnoides on depression and neurochemical pathways. The review article was generated by analyzing data and studies to establish the correlation between vitamin B12 and depression.