Ventilation-perfusion Scan: A Functional Imaging Approach to Regional Lung Disease in Primary Ciliary Dyskinesia

Introduction: [c.921+3_921+6delAAGT] gene, common in Puerto Rico, impairs ciliary function and contributes to progressive lung disease. Today, the clinical value of ventilation/perfusion (V/Q) scans in PCD has not been thoroughly investigated as well as pulmonary function tests (PFTs) and chest imaging. To explore the role and clinical utility of V/Q scans in PCD. Methods: -associated PCD. Results: decline and severity of bronchiectasis on chest imaging were depicted in V/Q scans. Discussion: These findings suggest that V/Q scans can provide additional functional and physiological information beyond that obtained from CT scans in patients with PCD. Furthermore, future longitudinal studies are needed to confirm their value for monitoring disease progression and guiding clinical care in PCD. Conclusion: V/Q scans may identify functional abnormalities in PCD and complement standard imaging and pulmonary function tests. These scans may serve as valuable tools for monitoring disease progression and informing clinical decision-making.