Flavonoid-Based Derivatives in Ovarian Cancer Treatment: Synthetic Methods, Biochemical Potential, and Translational Difficulties

Introduction: Ovarian cancer is a very fatal gynecologic tumor that is often diagnosed at late stages, hence reducing the availability of other treatment methods. Naturally occurring polyphenolic compounds, isolated in botanical sources and named Flavonoids, have already shown significant promise as anticancer agents because of their ability to prevent tumor growth, cause apoptosis, and alter critical signaling pathways with minimal toxicity and wide availability. Methods: The review is an in-depth analysis of recent studies that aim at synthesizing and assessing flavonoid derivatives in the context of ovarian cancer. A scientific search and survey were conducted in key scientific databases to locate the literature on the topic used the following search words: ovarian cancer and flavonoid derivatives. The discussion primarily focused on chemical synthesis, biological efficacy, and structure-activity relationship (SAR) of these compounds. Results: Many synthetic flavonoid derivatives, in particular triazole-linked, chalcone-based, and halogenated analogs, have exhibited high cytotoxic activity against ovarian cancer cell lines (IC 50