Liposome-based Pharmacotherapy for the Management of Psoriasis

The chronic inflammatory skin disease, psoriasis, affects a large number of people globally. It is typified by immune system malfunction that results in a range of symptoms. The primary goal of conventional drug delivery methods for psoriasis treatment is to alleviate symptoms; however, these methods frequently fall short due to their poor safety and efficacy, low bioavailability, and limited effectiveness. Consequently, there has been an increase in interest in creating innovative drug delivery systems that might overcome these drawbacks. Liposomes, transferosomes, ethosomes, niosomes, emulsomes, dendrimers, hydrogels, nanoparticles, and others are examples of these novel drug delivery methods. Through modifications to pharmacokinetic and physiological factors, these formulations aim to enhance the therapeutic effects of medications. Liposomes are one of these systems that are the most promising for delivering medications to treat psoriasis. Liposomes are lipid bilayer-based tiny vesicles that can enhance the penetration of medications through the stratum corneum, the outermost layer of the skin. When applied topically, this increased penetration can improve the delivery of medications into or through the skin. Improved therapeutic results are a result of liposomes' many benefits, which include longer drug release and enhanced stability. The potential of liposomes as a drug delivery mechanism for treating psoriasis is the main topic of this chapter. By encapsulating anti-psoriatic medications inside liposomes, researchers aim to enhance treatment efficiency and target areas affected by psoriasis. Treating psoriasis with liposomes has the potential to enhance patient outcomes by overcoming the limitations of traditional drug delivery methods. In conclusion, the development of innovative medication delivery methods, such as liposomes, offers a viable strategy for managing psoriasis. Through the utilisation of liposomes' distinct characteristics, such as their enhanced drug penetration and extended release, scientists aim to augment the therapeutic outcomes of pharmaceuticals and improve the overall treatment of psoriasis.