Emulsomes-Based Pharmacotherapy for the Management of Psoriasis

Background: Psoriasis is an inflammatory, autoimmune skin condition that is driven by T cells & is characterized by abnormal keratinization, hyperkeratosis, angiogenesis, and inflammation of the skin's surface. There are now many different pharmacotherapies for it; nevertheless, standard formulation-based pharmacotherapy can only partially improve treatment outcomes. Recent developments in nanomedicine based on nanotechnology may make pharmacotherapeutic drugs for psoriasis more safe and effective. Objective: The objective is to offer a comprehensive overview of the development & utilization of emulsomes for targeted delivery of anti-psoriatic agents. This addresses the various drugs, the pathophysiology of psoriasis in short, and the therapeutic issues that come with it. Below, we have discussed the collective reports of several medications operating on distinct psoriasis molecular targets as well as the function of nanomedicine in their efficient targeting. Methods: The formulation techniques involved in preparing emulsomes loaded with anti-psoriatic drugs highlight the key parameters considered for their optimization. Various methods for characterizing emulsomes, such as particle size analysis, encapsulation efficiency determination, & surface morphology examination, are elaborated. The in vitro & in vivo experimental methods employed to assess drug release, skin permeation, and therapeutic efficacy are also detailed.Results: Emulsomes-based formulations demonstrated superior encapsulation efficiency, sustained drug release, and enhanced skin penetration, leading to improved therapeutic outcomes in psoriasis management. Experimental findings and comparative analyses reveal the advantages of emulsomes over conventional drug delivery systems.Conclusion: Emulsomes-based pharmacotherapy presents a promising approach for targeted and efficient management of psoriasis. The chapter focuses on emphasizing emulsomes' potential to revolutionize psoriasis treatment paradigms and highlighting future research directions in this field.