Nanoemulsions-Based System for the Management of Psoriasis

The word “psoriasis” comes from the Ancient Greek word “psora,” which means “itch.” Severe itching is a common symptom of psoriasis, a chronic, noncontagious, inherited skin condition. It is an immune-mediated condition characterised by both hyperproliferation and inadequate keratinocyte differentiation in the epidermis of the skin. Although only affecting 2-3% of the population, this immune-mediated skin condition has a major harmful effect on the patient's quality of life. Although they have demonstrated poor efficacy and lack aesthetic value, topical psoriatic therapies such as emollients, coal tar, and dithranol are safer. Many strategies have been investigated by modern medicine to treat this condition (such as injectables, oral medication, and steroid-based lotions). However, none of these approaches have proven successful, as they lack an ideal and safe carrier that can deliver the antipsoriatic medication to the patient safely and effectively, thereby achieving the greatest possible therapeutic impact. Researchers are working with nanotechnology to overcome the shortcomings of traditional treatments, aiming to improve the effectiveness of anti-psoriatic drug delivery and reduce its unfavourable side effects. Utilising a colloidal model, nanoemulsion is a technique that applies high surface area active substances in the form of nanosized droplets to the skin's afflicted area. A number of advantages over traditional delivery methods are provided by nanoemulsions, which include decreased drug degradation and loss, avoided hazardous side effects, and higher drug bioavailability. Compared to coarse emulsions, nanoemulsions exhibit greater kinetic stability, prevent cream separation, significantly influence topical systems, and have a higher solubilization capacity.Significant research on nanoemulsion-loaded antipsoriatic medicines has previously been done. Many antipsoriatic drugs, including Capsaicin, Aceclofenac, Turmeric oil, Calcipotriol, Betamethasone Dipropionate, salicylic acid, Clobetasol propionate and others have been loaded into nanoemulsion using various preparation methods.