Comparative Antimicrobial Activity of Lead (Naga Anjana Shalaka) Enriched Drug Sample (Rasanjana) against Staphylococcus Aureus and Staphylococcus Epidermidis: A Potential Therapeutic approach in Blepharitis Management

Blepharitis is a common, chronic inflammatory eyelid condition frequently associated with bacterial colonization, particularly by Staphylococcus aureus and Staphylococcus epidermidis. Current treatment protocols largely depend on antibiotics and anti-inflammatory agents; however, recurrence and antimicrobial resistance remain major challenges. The present study evaluated the antimicrobial activity of a drug formulation and its lead-containing modification against S. aureus and S. epidermidis using the agar well diffusion assay. The results demonstrated that while the control drug was effective only against S. aureus (10 mm inhibition zone), the lead-containing formulation exhibited activity against both organisms (S. aureus – 11 mm, S. epidermidis – 13 mm). These findings suggest that incorporation of lead enhances antibacterial efficacy and broadens the antimicrobial spectrum. This modified drug formulation may have significant implications for the treatment of staphylococcal blepharitis, though further pre-clinical and clinical studies are warranted.