Mechanistic Insights into Melatonin–Calcitonin–Dependent Regulation of Osteoclast Activity Using Goldfish Scales

Biological Sciences in Space 2026 Open access

Read full text
Authors: Jun Hirayama, Harumi Takino, Yusuke Maruyama, Mika Ikegame, Yoshiaki Tabuchi, Hajime Matsubara, Nobuaki Shimizu, Hiroyuki Mishima, Atsuhiko Hattori, Nobuo Suzuki
DOI: 10.2187/bss.40.1
Cited by: 0
References: 40

Abstract

Exposure to microgravity during spaceflight induces excessive osteoclast activation, resulting in bone loss and dysregulation of calcium metabolism. Accumulating evidence from spaceflight and ground-based studies suggests that endocrine factors involved in osteoclast inhibition may be altered under microgravity conditions; however, the underlying regulatory mechanisms remain incompletely understood.

Fields of Study & Subjects

Spaceflight effects on biology Bone Metabolism and Diseases Bone health and osteoporosis research

Publication details

Journal / source
Biological Sciences in Space
Volume
40
Issue
0
Pages
1–7
Publication date
1 January 2026
Language
EN